Serotonin syndrome – this is caused by excessive levels of serotonin in the body and is more likely to occur with higher dosages of SSRIs or SNRIs, or when SSRIs or SNRIs are administered with other medications that also release serotonin (such as dextromethorphan, tramadol, and St.This is most likely to occur when starting therapy An increase in suicidal thoughts and behaviors, particularly in children and young adults under the age of 25 years.Sexual dysfunction (such as reduced desire or erectile dysfunction).Gastrointestinal upset (such as constipation, diarrhea, or nausea).Drowsiness (fluoxetine is more likely to cause insomnia).Commonly reported side effects that may occur with either SSRIs or SNRIs include: SSRIs and SNRIs have similar side effects. In addition to depression, some SNRIs are approved to treat:ĭo SSRIs and SNRIs have different side effects? Other conditions that SSRIs are approved to treat, in addition to depression, include: SSRIs tend to be more commonly prescribed than SNRIs because they are effective at improving mood and tend to be less likely than some SNRIs to cause side effects. What conditions do SSRIs and SNRIs treat? We know now it’s not that simple, but well-conducted trials have shown that antidepressants such as SSRIs and SNRIs are beneficial for depression which is why they are commonly prescribed. In the past, depression has been thought to be caused by a chemical imbalance in the brain or by a deficiency in serotonin. The truth is, experts, don’t really know what causes depression, or even how antidepressants work. The benefits of antidepressants such as SSRIs and SNRIs are thought to be due to their effect on neurotransmitters, or the effect keeping them in the nerve synapse for longer has on the way the brain operates. This means that the neurotransmitter stays for a longer period in the gap between the two nerve cells (the gap is called the nerve synapse).
Both SSRIs and SNRIs are a type of reuptake inhibitor, which means that they prevent the neurotransmitter from being reabsorbed back into the nerve cell that released it. Reuptake is the process in which the neurotransmitter is reabsorbed back into the nerve cell once the stimulus has passed. Neurotransmitters may also be called chemical messengers. Neurotransmitters are chemicals which nerve cells release to “talk” to other nerve cells.
SSRIs and SNRIs work similarly, that is by preventing the reuptake of certain neurotransmitters in the brain (SSRIs: serotonin SNRIs: serotonin and norepinephrine). SSRIs and SNRIs are two classes of medications that may be used for the treatment of depression, and sometimes for other conditions as well.Ĭommon SSRIs include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), and there are others.Ĭommon SNRIs include desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta, Irenka), venlafaxine (Effexor, Effexor XR), and there are others. SSRI stands for selective serotonin reuptake inhibitor and SNRI stands for serotonin and norepinephrine reuptake inhibitor. Serotonin and norepinephrine are substances that the brain uses to send messages from one nerve cell to another. The main difference between SSRIs and SNRIs is that SSRIs prevent the reuptake of serotonin and SNRIs prevent the reuptake of serotonin and norepinephrine.
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